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By 2050, India will see its over-60 population grow by 300 million or more and Africa alone will account for over 200 million dementia cases. 70 percent of all global cases will occur in low- and middle-income countries. But LMICs are not just the future epicenter of dementia burden; they are also home to the fastest-growing working-age populations on earth. A brain health crisis left unaddressed in these regions doesn’t stay there. It suppresses productivity, strains caregiving systems, and constrains the very economic growth that global supply chains, investment portfolios, and development strategies depend on. Investing in early detection and prevention infrastructure in the Global South is not charity. It is a hedge against the most predictable workforce disruption of the next half-century